PH- and ligand-induced release of loads from DNA-acrylamide hydrogel microcapsules.

ABSTRACT: Herein, a method to construct stimuli-responsive DNA-acrylamide-based hydrogel microcapsules has been presented. This method involves the use of polyacrylamide chains modified with predesigned nucleic acid hairpin units and optionally single-strand tethers that provide the required hybridization and recognition functions to yield substrate-loaded stimuli-responsive hydrogel-based microcapsules. The synthesis of the microcapsules involves the loading of CaCO₃ microparticles with the respective load substrates and the functionalization of the CaCO₃ template particles with nucleic acid promoter units. In the presence of the hairpin-modified acrylamide chains, the promoter units induce the hybridization chain reaction (HCR), which leads to the formation of a hydrogel coat

SUBMITTER: Liao WC 

PROVIDER: S-EPMC5416914 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature