Bombesin receptor subtype 3 as a potential target for obesity and diabetes.

ABSTRACT:

Introduction

Diabetes mellitus and obesity are important health issues; increasing in prevalence, both in the USA and globally. There are only limited pharmacological treatments, and although bariatric surgery is effective, new effective pharmacologic treatments would be of great value. This review covers one area of increasing interest that could yield new novel treatments of obesity/diabetes mellitus. It involves recognition of the central role the G-protein-coupled receptor, bombesin receptor subtype 3 (BRS-3) plays in energy/glucose metabolism.

Areas covered

Since the initial observation that BRS-3 knockout mice develop obesity, hypertension, impaired glucose metabolism and hyperphagia, there have been numerous studies of the mechanisms involved and the development of se

SUBMITTER: Gonzalez N 

PROVIDER: S-EPMC5417335 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature