Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

ABSTRACT: The complement system is an elegantly regulated biochemical cascade formed by the collective molecular recognition properties and proteolytic activities of more than two dozen membrane-bound or serum proteins. Complement plays diverse roles in human physiology, such as acting as a sentry against invading microorganisms, priming of the adaptive immune response, and removal of immune complexes. However, dysregulation of complement can serve as a trigger for a wide range of human diseases, which include autoimmune, inflammatory, and degenerative conditions. Despite several potential advantages of modulating complement with small-molecule inhibitors, small-molecule drugs are highly underrepresented in the current complement-directed therapeutics pipeline. In this study, we have employed a chem

SUBMITTER: Garcia BL 

PROVIDER: S-EPMC5417336 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature