Poractant alfa versus bovine lipid extract surfactant for infants 24+0 to 31+6 weeks gestational age: A randomized controlled trial.

ABSTRACT:

Objectives

To compare the efficacy and safety of poractant alfa and bovine lipid extract surfactant in preterm infants.

Study design

Randomized, partially-blinded, multicenter trial. Infants <32 weeks needing surfactant before 48 hours were randomly assigned to receive poractant alfa or bovine lipid extract surfactant. The primary outcome was being alive and extubated at 48 hours post-randomization. Secondary outcomes included need for re-dosing, duration of respiratory support and oxygen, bronchopulmonary dysplasia, mortality and complications during administration.

Results

Three centers recruited 87 infants (mean 26.7 weeks and 906 grams) at a mean age of 5.9 hours, between March 2013 and December 2015. 21/42 (50%) were alive and extubated at 48 hours in the poracta

SUBMITTER: Lemyre B 

PROVIDER: S-EPMC5417427 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature