Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors.

ABSTRACT:

Background

Most patients with early stage triple negative breast cancer (TNBC) receive adjuvant chemotherapy. Activation of the immune system is associated with tumor response and may help identify TNBC with favorable outcome.

Methods

Gene expression data were obtained from the GEO Dataset GDS2250/GSE3744. Affymetrix CEL files were downloaded and analyzed with Affymetrix Transcriptome Analysis Console 3.0. Functional genomics was implemented with David Bioinformatics Resources 6.8. Data contained at Oncomine were used to identify genes upregulated in basal-like cancer compared to normal breast tissue. Data contained at cBioportal were used to assess for molecular alterations. The KMPlotter online tool, METABRIC and GSE25066 datasets were used to associate gene signatures wit

SUBMITTER: Martinez-Canales S 

PROVIDER: S-EPMC5417488 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature