Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.

ABSTRACT:

Background and objective

Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility.

Methods

One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models.

Results

Significant differences were observed between EH cases and controls at the level of both gen

SUBMITTER: Wu Y 

PROVIDER: S-EPMC5417637 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature