Comorbidity and progression of late onset Alzheimer's disease: A systematic review.

ABSTRACT:

Background

Alzheimer's disease is a neurodegenerative syndrome characterized by multiple dimensions including cognitive decline, decreased daily functioning and psychiatric symptoms. This systematic review aims to investigate the relation between somatic comorbidity burden and progression in late-onset Alzheimer's disease (LOAD).

Methods

We searched four databases for observational studies that examined cross-sectional or longitudinal associations of cognitive or functional or neuropsychiatric outcomes with comorbidity in individuals with LOAD. From the 7966 articles identified originally, 11 studies were included in this review. The Newcastle-Ottawa quality assessment was used. The large variation in progression measures, comorbidity indexes and study designs hampered the a

SUBMITTER: Haaksma ML 

PROVIDER: S-EPMC5417646 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature