CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma.

ABSTRACT:

Background

Allergic asthma is a chronic airway inflammatory disease involving the complementary actions of innate and adaptive immune responses. Endogenously generated cannabinoids acting via CB2 receptors play important roles in both homeostatic and inflammatory processes. However, the contribution of CB2-acting eicosanoids to the innate events preceding sensitization to the common house dust mite (HDM) allergen remains to be elucidated. We investigated the role of CB2 activation during allergen-induced pulmonary inflammation and natural killer (NK) cell effector function.

Methods

Lung mucosal responses in CB2-deficient (CB2^-/- ) mice were examined and compared with wild-type (WT) littermates following intranasal exposure to HDM allergen.

Results

Mice lack

SUBMITTER: Ferrini ME 

PROVIDER: S-EPMC5418123 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature