Vitamin D₃ supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR^-/- and LDLR^+/+ mice.

ABSTRACT:

Introduction

Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D₃ , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.

Methods

We analyzed female LDLR^-/- and LDLR^+/+ mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation.

Results

The groups on a high fat high sugar diet with supplementary Vitamin D₃ , in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there

SUBMITTER: Kheder R 

PROVIDER: S-EPMC5418139 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature