Delayed Otolith Development Does Not Impair Vestibular Circuit Formation in Zebrafish.

ABSTRACT: What is the role of normally patterned sensory signaling in development of vestibular circuits? For technical reasons, including the difficulty in depriving animals of vestibular inputs, this has been a challenging question to address. Here we take advantage of a vestibular-deficient zebrafish mutant, rock solo ^AN66 , in order to examine whether normal sensory input is required for formation of vestibular-driven postural circuitry. We show that the rock solo ^AN66 mutant is a splice site mutation in the secreted glycoprotein otogelin (otog), which we confirm through both whole genome sequencing and complementation with an otog early termination mutant. Using confocal microscopy, we find that elements of postural circuits are anatomically normal in rock solo ^AN66</

SUBMITTER: Roberts R 

PROVIDER: S-EPMC5418161 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature