Parallel evolution of genes controlling mitonuclear balance in short-lived annual fishes.

ABSTRACT: The current molecular understanding of the aging process derives almost exclusively from the study of random or targeted single-gene mutations in highly inbred laboratory species, mostly invertebrates. Little information is available as to the genetic mechanisms responsible for natural lifespan variation and the evolution of lifespan, especially in vertebrates. Here, we investigated the pattern of positive selection in annual (i.e., short-lived) and nonannual (i.e., longer-lived) African killifishes to identify a genomic substrate for evolution of annual life history (and reduced lifespan). We identified genes under positive selection in all steps of mitochondrial biogenesis: mitochondrial (mt) DNA replication, transcription from mt promoters, processing and stabilization of mt RNAs, mt tr

SUBMITTER: Sahm A 

PROVIDER: S-EPMC5418189 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature