Decoding the complex genetic causes of heart diseases using systems biology.

ABSTRACT: The pace of disease gene discovery is still much slower than expected, even with the use of cost-effective DNA sequencing and genotyping technologies. It is increasingly clear that many inherited heart diseases have a more complex polygenic aetiology than previously thought. Understanding the role of gene-gene interactions, epigenetics, and non-coding regulatory regions is becoming increasingly critical in predicting the functional consequences of genetic mutations identified by genome-wide association studies and whole-genome or exome sequencing. A systems biology approach is now being widely employed to systematically discover genes that are involved in heart diseases in humans or relevant animal models through bioinformatics. The overarching premise is that the integration of high-quali

SUBMITTER: Djordjevic D 

PROVIDER: S-EPMC5418423 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature