SH3 domains: modules of protein-protein interactions.

ABSTRACT: Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.

SUBMITTER: Kurochkina N 

PROVIDER: S-EPMC5418429 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature