High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients.

ABSTRACT:

Background

Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. Despite several reports, its roles in gastric cancer (GC) remain unclear owing to a lack of analyses of highly metastatic cases. This study aimed to investigate STMN1 as a prognostic and predictive indicator of response to paclitaxel therapy in patients with GC, including inoperable cases.

Methods

Immunohistochemical analysis of STMN1 was performed on both operable (n=95) and inoperable GC (n=61) samples. The roles of STMN1 in cancer cell proliferation and sensitivity to a microtubule-targeting drug, paclitaxel, were confirmed by knockdown experiments using GC cell lines.

Results

Multivariate and Kaplan-Meier analyses demonst

SUBMITTER: Bai T 

PROVIDER: S-EPMC5418450 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature