SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour.

ABSTRACT:

Background

The SLUG transcription factor has been linked with the KIT signalling pathway that is important for gastrointestinal stromal tumour (GIST) tumourigenesis. Its clinical significance in GIST is unknown.

Methods

Influence of SLUG expression on cell proliferation and viability were investigated in GIST48 and GIST882 cell lines. The association between tumour SLUG expression in immunohistochemistry and recurrence-free survival (RFS) was studied in two clinical GIST series, one with 187 patients treated with surgery alone, and another one with 313 patients treated with surgery and adjuvant imatinib.

Results

SLUG downregulation inhibited cell proliferation, induced cell death in both cell lines, and sensitised GIST882 cells to lower imatinib concentrations. SLUG w

SUBMITTER: Pulkka OP 

PROVIDER: S-EPMC5418455 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature