Acid-suppressing therapies and subsite-specific risk of stomach cancer.

ABSTRACT:

Background

Associations of stomach cancer risk with histamine type-2 receptor antagonists (H₂RA) and proton-pump inhibitors (PPI) are controversial. We hypothesised that proximal extension of Helicobacter pylori infection from acid suppression would disproportionately increase cancers at proximal subsites.

Methods

A total of 1 563 860 individuals in the Danish Prescription Drug Registry first prescribed acid-suppressive drugs 1995-2011 were matched to unexposed population-based controls. Hazard ratios (HR) were calculated by Cox proportional hazard regression for stomach cancers diagnosed more than one year after first prescription.

Results

There were 703 stomach cancers among H₂RA-exposed individuals and 1347 among PPI-exposed. Restricted to ind

SUBMITTER: Wennerstrom ECM 

PROVIDER: S-EPMC5418456 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature