T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10.

ABSTRACT: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4⁺CD25⁺FoxP3⁺ T regulatory cells (Tregs) and CD11c⁺ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. I

SUBMITTER: Kapur R 

PROVIDER: S-EPMC5418638 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature