Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

ABSTRACT:

Background

The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease. We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent coronary heart disease.

Methods and results

We studied a total of 25 109 European ancestry and African ancestry participants with coronary artery calcification (CAC) measured by cardiac computed tomography and 52 869 participants with common carotid intima-media thickness measured by ultrasonography within the CHARGE Consortium (Cohorts for Heart and Aging Research in Genomic Epidemiology). Participants were genotyped for 247 870 DNA sequence variants (231 539 in exons)

SUBMITTER: Natarajan P 

PROVIDER: S-EPMC5418659 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature