Increased lignocellulosic inhibitor tolerance of Saccharomyces cerevisiae cell populations in early stationary phase.

ABSTRACT:

Background

Production of second-generation bioethanol and other bulk chemicals by yeast fermentation requires cells that tolerate inhibitory lignocellulosic compounds at low pH. Saccharomyces cerevisiae displays high plasticity with regard to inhibitor tolerance, and adaptation of cell populations to process conditions is essential for reaching efficient and robust fermentations.

Results

In this study, we assessed responses of isogenic yeast cell populations in different physiological states to combinations of acetic acid, vanillin and furfural at low pH. We found that cells in early stationary phase (ESP) exhibited significantly increased tolerance compared to cells in logarithmic phase, and had a similar ability to initiate growth in the presence of inhibitors as pr

SUBMITTER: Narayanan V 

PROVIDER: S-EPMC5418707 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature