Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity.

ABSTRACT:

Background

As the primary immune response cell in the central nervous system, microglia constantly monitor the microenvironment and respond rapidly to stress, infection, and injury, making them important modulators of neuroinflammatory responses. In diseases such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and human immunodeficiency virus-induced dementia, activation of microglia precedes astrogliosis and overt neuronal loss. Although microgliosis is implicated in manganese (Mn) neurotoxicity, the role of microglia and glial crosstalk in Mn-induced neurodegeneration is poorly understood.

Methods

Experiments utilized immunopurified murine microglia and astrocytes using column-free magnetic separation. The effect of Mn on microglia was investigated using g

SUBMITTER: Kirkley KS 

PROVIDER: S-EPMC5418760 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature