Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep.

ABSTRACT:

Background

A study to investigate transmission of classical scrapie via goat milk was carried out in sheep: firstly, lambs were challenged orally with goat scrapie brain homogenate to confirm transmission of scrapie from goats to sheep. In the second study phase, milk from scrapie-infected goats was fed to lambs. Lambs were selected according to their prion protein gene (PRNP) genotype, which was either VRQ/VRQ or ARQ/ARQ, with or without additional polymorphisms at codon 141 (FF₁₄₁, LF₁₄₁ or LL₁₄₁) of the ovine PRNP. This report describes the clinical, pathological and molecular phenotype of goat scrapie in those sheep that progressed to clinical end-stage.

Results

Ten sheep (six VRQ/VRQ and four ARQ/ARQ, of which three FF₁₄₁ and

SUBMITTER: Konold T 

PROVIDER: S-EPMC5418773 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature