Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection.

ABSTRACT:

Background

MicroRNAs (miRNAs) control multiple biological processes including the innate immune responses by negative post-transcriptional regulation of gene expression. As there were no studies on the role(s) of miRNAs in viral diseases in Atlantic salmon, we aimed to identify miRNAs responding to salmonid alphavirus (SAV) infection. Their expression were studied at different time points post infection with SAV isolates associated with different mortalities. Furthermore, the genome sequences of the identified miRNAs were analysed to reveal putative cis-regulatory elements, and, finally, their putative target genes were predicted.

Results

Twenty differentially expressed miRNAs (DE miRNAs) were identified. The expression of the majority of these increased post infection with

SUBMITTER: Andreassen R 

PROVIDER: S-EPMC5418855 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature