Long noncoding RNAs: New evidence for overlapped pathogenesis between major depressive disorder and generalized anxiety disorder.

ABSTRACT:

Background

About half of patients with major depressive disorder (MDD) have clinically meaningful levels of anxiety. Greater severity of depressive illness and functional impairment has been reported in patients with high levels of anxiety accompanying depression. The pathogenesis for the comorbidity was still unsure.

Aim

This study aimed to determine whether there would be molecular link for overlapped pathogenesis between MDD and anxiety disorder.

Materials and methods

Using long noncoding RNA (lncRNA) microarray profiling and reverse transcription polymerase chain reaction, six downregulated lncRNAs and three upregulated lncRNAs had been identified to be the potential biomarkers for MDD and generalized anxiety disorder (GAD), respectively. Then, the lncRNAs were cr

SUBMITTER: Cui X 

PROVIDER: S-EPMC5419018 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature