Exogenous thyroxine improves glucose intolerance in insulin-resistant rats.

ABSTRACT: Both hypothyroidism and hyperthyroidism are associated with glucose intolerance, calling into question the contribution of thyroid hormones (TH) on glucose regulation. TH analogues and derivatives may be effective treatment options for glucose intolerance and insulin resistance (IR), but their potential glucoregulatory effects during conditions of impaired metabolism are not well described. To assess the effects of thyroxine (T₄) on glucose intolerance in a model of insulin resistance, an oral glucose tolerance test (oGTT) was performed on three groups of rats (n = 8): (1) lean, Long Evans Tokushima Otsuka (LETO), (2) obese, Otsuka Long Evans Tokushima Fatty (OLETF) and (3) OLETF + T₄ (8.0 µg/100 g BM/day × 5 weeks). T₄ attenuated glucose intolerance by 15%

SUBMITTER: Vazquez-Anaya G 

PROVIDER: S-EPMC5419047 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature