Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

ABSTRACT: Acquired resistance to chemotherapy remains a major stumbling block in cancer treatment. Chronic inflammation has a crucial role in induction of chemoresistance and results, in part, from the induction and expansion of inflammatory cells that include myeloid-derived suppressor cells (MDSCs) and IL-13⁺ Th2 cells. The mechanisms that lead to induction of activated MDSCs and IL-13⁺ Th2 cells have not yet been identified. Here we demonstrated that doxorubicin (DOX) treatment of 4T1 breast tumor-bearing mice led to the induction of IL-13R⁺miR-126a⁺ MDSCs (DOX-MDSC). DOX-MDSC promote breast tumor lung metastasis through MDSC miR-126a⁺ exosomal-mediated induction of IL-13⁺ Th2 cells and tumor angiogenesis. The induction of DOX-MDSC

SUBMITTER: Deng Z 

PROVIDER: S-EPMC5419051 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature