Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation.

ABSTRACT: Circadian rhythms are observed in nearly all aspects of physiology and behavior. In mammals, such biological rhythms are supported by a complex network of self-sustained transcriptional loops and posttranslational modifications, which regulate timely controlled production and degradation of critical factors on a 24-h basis. Among these factors, the orphan nuclear receptor rev-erbalpha plays an essential role by linking together positive and negative regulatory loops. As an essential part of the circadian core clock mechanism, REV-ERBalpha expression shows a precisely scheduled oscillation reflecting the tight control of its production and degradation. In previous studies, we identified two alternative transcripts encoding two protein variants referred to as REV-ERBalpha1 and -alpha2. Inter

SUBMITTER: Rambaud J 

PROVIDER: S-EPMC5419257 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature