Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores.

ABSTRACT: Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. While many AMD susceptibility variants have been identified, their influence on AMD progression has not been elucidated. Using data from two large clinical trials, Age-Related Eye Disease Study (AREDS) and AREDS2, we evaluated the effects of 34 known risk variants on disease progression. In doing so, we calculated the eye-level time-to-late AMD and modeled them using a bivariate survival analysis approach, appropriately accounting for between-eye correlation. We then derived a genetic risk score (GRS) based on these 34 risk variants, and analyzed its effect on AMD progression. Finally, we used the AREDS data to fit prediction models of progression based on demographic and environmental factors, e

SUBMITTER: Ding Y 

PROVIDER: S-EPMC5419464 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature