A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in Drosophila.

ABSTRACT: Meiotic drive occurs when a selfish element increases its transmission frequency above the Mendelian ratio by hijacking the asymmetric divisions of female meiosis. Meiotic drive causes genomic conflict and potentially has a major impact on genome evolution, but only a few drive loci of large effect have been described. New methods to reliably detect meiotic drive are therefore needed, particularly for discovering moderate-strength drivers that are likely to be more prevalent in natural populations than strong drivers. Here, we report an efficient method that uses sequencing of large pools of backcross (BC1) progeny to test for deviations from Mendelian segregation genome-wide with single-nucleotide polymorphisms (SNPs) that distinguish the parental strains. We show that meiotic drive can b

SUBMITTER: Wei KH 

PROVIDER: S-EPMC5419488 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature