Dioxins and related environmental contaminants increase TDP-43 levels.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the accumulation of aggregated TAR DNA Binding Protein-43 (TDP-43, gene: TARDBP). Increasing evidence indicates that environmental factors contribute to the risk of ALS. Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor. Recently, exposure to these toxicants was identified as a risk factor for ALS.

Methods

We examined levels of TDP-43 reporter activity, transcript and protein. Quantification was done using cell lines, induced pluripotent s

SUBMITTER: Ash PEA 

PROVIDER: S-EPMC5420162 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature