Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change.

ABSTRACT: An increasing number of studies have implicated the role of network functional connectivity in addiction. Yet, none have examined functional connectivity as a potential mechanism of adolescent behavior change. We examined the underlying neural mechanism of a promising treatment for adolescents, motivational interviewing (MI). We began by employing psychophysiological interaction (PPI) to evaluate network response in a sample of adolescent cannabis users (N=30). Next, we examined correlations between network connectivity and clinical metrics of treatment outcome. PPI analyses seeded on the orbitofrontal cortex (OFC) showed significant increases in functional connectivity across the inferior frontal gyrus (IFG), precentral gyrus, anterior and posterior cingulate gyrus, supplementary motor ar

SUBMITTER: Feldstein Ewing SW 

PROVIDER: S-EPMC5420345 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature