Ontology highlight
ABSTRACT:
SUBMITTER: Hall EA
PROVIDER: S-EPMC5420347 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
American journal of human genetics 20170413 5
During neurotransmission, synaptic vesicles undergo multiple rounds of exo-endocytosis, involving recycling and/or degradation of synaptic proteins. While ubiquitin signaling at synapses is essential for neural function, it has been assumed that synaptic proteostasis requires the ubiquitin-proteasome system (UPS). We demonstrate here that turnover of synaptic membrane proteins via the endolysosomal pathway is essential for synaptic function. In both human and mouse, hypomorphic mutations in the ...[more]