'Waiting impulsivity' in isolation-reared and socially-reared rats: effects of amphetamine.

ABSTRACT:

Background

Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine.

Methods

Using an isolation-rearing (IR) manipulation, the present study examined the effects of IR on impulsive action and impulsive choice when also treated with doses of D-amphetamine, by employing the five-choice serial reaction time task (5-CSRTT) and a temporal discounting of reward task (TDRT), respectively.

Results

IR rats showed similar acquisition of the 5-CSRTT. Amphetamine increased premature responding in both groups; however, IR rats showed less responding overall. For

SUBMITTER: Liu YP 

PROVIDER: S-EPMC5420383 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature