Neuropeptide systems and new treatments for nicotine addiction.

ABSTRACT:

Rationale

The mildly euphoric and cognitive enhancing effects of nicotine play a role in the initiation of smoking, while dysphoria and anxiety associated with smoking cessation contribute to relapse. After the acute withdrawal phase, smoking cues, a few cigarettes (i.e., lapse), and stressors can cause relapse. Human and animal studies have shown that neuropeptides play a critical role in nicotine addiction.

Objectives

The goal of this paper is to describe the role of neuropeptide systems in the initiation of nicotine intake, nicotine withdrawal, and the reinstatement of extinguished nicotine seeking.

Results

The reviewed studies indicate that several drugs that target neuropeptide systems diminish the rewarding effects of nicotine by preventing the activation of dop

SUBMITTER: Bruijnzeel AW 

PROVIDER: S-EPMC5420481 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature