Screening of conventional anticonvulsants in a genetic mouse model of epilepsy.

ABSTRACT:

Objective

Epilepsy is a common neurological disorder that affects 1% of the population. Approximately, 30% of individuals with epilepsy are refractory to treatment, highlighting the need for novel therapies. Conventional anticonvulsant screening relies predominantly on induced seizure models. However, these models may not be etiologically relevant for genetic epilepsies. Mutations in SCN1A are a common cause of Dravet Syndrome, a severe epileptic encephalopathy. Dravet syndrome typically begins in infancy with seizures provoked by fever and then progresses to include afebrile pleomorphic seizure types. Affected children respond poorly to available anticonvulsants. Scn1a^+/- heterozygous knockout mice recapitulate features of Dravet syndrome and provide a pot

SUBMITTER: Hawkins NA 

PROVIDER: S-EPMC5420810 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature