Identification of "BRAF-Positive" Cases Based on Whole-Slide Image Analysis.

ABSTRACT: A key requirement for precision medicine is the accurate identification of patients that would respond to a specific treatment or those that represent a high-risk group, and a plethora of molecular biomarkers have been proposed for this purpose during the last decade. Their application in clinical settings, however, is not always straightforward due to relatively high costs of some tests, limited availability of the biological material and time, and procedural constraints. Hence, there is an increasing interest in constructing tissue-based surrogate biomarkers that could be applied with minimal overhead directly to histopathology images and which could be used for guiding the selection of eventual further molecular tests. In the context of colorectal cancer, we present a method for constru

SUBMITTER: Popovici V 

PROVIDER: S-EPMC5421098 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature