Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats.

ABSTRACT:

Background

Although clinical vitamin A deficiency (VAD), which is a public health problem developing throughout the world, has been well controlled, marginal vitamin A deficiency (MVAD) is far more prevalent, especially among pregnant women and preschool children in China. Increasing evidence suggests that VAD is involved in the pathogenesis of Alzheimer's disease (AD). However, whether MVAD, beginning early in life, increases the risk of developing AD has yet to be determined.

Objective

The goal of this study was to investigate the long-term effects of MVAD on the pathogenesis of AD in rats.

Method

An MVAD model was generated from maternal MVAD rats and maintained with an MVAD diet after weaning. The males were bilaterally injected with aggregated amyloid β (Aβ)1-42

SUBMITTER: Zeng J 

PROVIDER: S-EPMC5421133 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature