Dengue virus serological prevalence and seroconversion rates in children and adults in Medellin, Colombia: implications for vaccine introduction.

ABSTRACT:

Background

Dengue is an important public health problem worldwide. A vaccine has recently been licensed in some countries of Latin America and Asia. Recommendations for dengue vaccine introduction include endemicity and a high serological prevalence of dengue in the territories considering its introduction.

Methods

A community-based survey was conducted to estimate dengue seroprevalence and age-specific seroconversion rates in a community in Medellin, Colombia, using a dengue serological test (IgG indirect ELISA). Residents were selected at random and were first screened for dengue infection; they were then followed over 2.5 years.

Results

A total of 3684 individuals aged between 1 and 65 years participated in at least one survey. The overall dengue seroprevalence was

SUBMITTER: Carabali M 

PROVIDER: S-EPMC5421161 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature