Impact of rs12979860 polymorphism on liver morphology in chronic HCV infection.

ABSTRACT:

Aim of the study

To determine distribution of rs12979860 genotypes, their correlations with viral load as well as inflammatory activity and stage of liver fibrosis in patients infected with HCV genotype 1.

Material and methods

The study included 132 patients infected with HCV genotype 1b. Serum viral loads were obtained with the PCR method. Rs12979860 polymorphisms were determined by sequencing of PCR products. Liver biopsy was performed in all patients.

Results

CT, TT and CC alleles of rs12979860 polymorphism were detected in 58%, 20% and 22% of patients respectively. The highest viral load was observed in the TT and the lowest in the CC group (72.0 × 10⁶ IU/ml vs. 2.1 × 10⁶ IU/ml, p < 0.005). A significant correlation was demonstrated be

SUBMITTER: Lapinski TW 

PROVIDER: S-EPMC5421166 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature