Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses.

ABSTRACT:

Background

Unlike the well-studied backer yeast where catabolite repression represents a burden for mixed substrate fermentation, Yarrowia lipolytica, an oleaginous yeast, is recognized for its potential to produce single cell oils and citric acid from different feedstocks. These versatilities of Y. lipolytica with regards to substrate utilization make it an attractive host for biorefinery application. However, to develop a commercial process for the production of citric acid by Y. lipolytica, it is necessary to better understand the primary metabolism and its regulation, especially for growth on mixed substrate.

Results

Controlling the dissolved oxygen concentration (pO₂) in Y. lipolytica cultures enhanced citric acid production significantly in cultures grown on

SUBMITTER: Sabra W 

PROVIDER: S-EPMC5421321 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature