Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study.

ABSTRACT: Objective To examine long term cardiorenal outcomes associated with increased concentrations of creatinine after the start of angiotensin converting enzyme inhibitor/angiotensin receptor blocker treatment.Design Population based cohort study using electronic health records from the Clinical Practice Research Datalink and Hospital Episode Statistics.Setting UK primary care, 1997-2014.Participants Patients starting treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blockers (n=122 363).Main outcome measures Poisson regression was used to compare rates of end stage renal disease, myocardial infarction, heart failure, and death among patients with creatinine increases of 30% or more after starting treatment against those without s

SUBMITTER: Schmidt M 

PROVIDER: S-EPMC5421447 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature