Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies.

ABSTRACT: Objective To compare the risk for all cause and overdose mortality in people with opioid dependence during and after substitution treatment with methadone or buprenorphine and to characterise trends in risk of mortality after initiation and cessation of treatment.Design Systematic review and meta-analysis.Data sources Medline, Embase, PsycINFO, and LILACS to September 2016.Study selection Prospective or retrospective cohort studies in people with opioid dependence that reported deaths from all causes or overdose during follow-up periods in and out of opioid substitution treatment with methadone or buprenorphine.Data extraction and synthesis Two independent reviewers performed data extraction and assessed study quality. Mortality rates in and out of treatm

SUBMITTER: Sordo L 

PROVIDER: S-EPMC5421454 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature