Optimal flow rate sampling designs for studies with extended exhaled nitric oxide analysis.

ABSTRACT:

Introduction

The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation. Repeat FeNO maneuvers at multiple fixed exhalation flow rates (extended NO analysis) can be used to estimate parameters quantifying proximal and distal sources of NO in mathematical models of lower respiratory tract NO. A growing number of studies use extended NO analysis, but there is no official standard flow rate sampling protocol. In this paper, we provide information for study planning by deriving theoretically optimal flow rate sampling designs.

Methods

First, we reviewed previously published designs. Then, under a nonlinear regression framework for estimating NO parameters in the steady-state two compartment model of NO, we identified unbiased optimal four f

SUBMITTER: Molshatski N 

PROVIDER: S-EPMC5421556 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature