Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression.

ABSTRACT:

Background

One prominent event associated with colorectal adenoma-to-carcinoma progression is genomic instability. Approximately 85% of colorectal cancer cases exhibit chromosomal instability characterized by accumulation of chromosome copy number aberrations (CNAs). Adenomas with gain of chromosome 8q, 13q, and/or 20q are at high risk of progression to cancer. Tumor progression is also associated with expansion of the extracellular matrix (ECM) and the activation of non-malignant cells within the tumor stroma. The glycoproteins versican and lumican are overexpressed at the mRNA level in colon carcinomas compared to adenomas, and are associated with the formation of tumor stroma.

Purpose

The aim of this study was to characterize versican and lumican protein expression in tum

SUBMITTER: de Wit M 

PROVIDER: S-EPMC5421768 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature