Low CCL-21 expression associates with unfavorable postoperative prognosis of patients with metastatic renal cell carcinoma.

ABSTRACT:

Background

Chemokine (C-C motif) ligand 21 (CCL21), a ligand of the chemokine (C-C motif) receptor 7, has recently been identified as an immuno-based anti-cancer molecule for its dendritic cells and T lymphocytes chemoattractant function. The aim of this study was to investigate prognostic values of CCL21 expression in metastatic renal cell carcinoma patients treated with targeted therapy.

Methods

This study included 111 patients with metastatic renal cell carcinoma receiving targeted therapy. CCL21 expression was analyzed by immunohistochemistry on tissue microarrays. Prognostic value of tumoral CCL21 expression and patients' clinical outcomes were evaluated.

Results

Kaplan-Meier method showed that low CCL21 expression was associated with shorter patient overall surv

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC5421958 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature