Autophagy-related genes in Helicobacter pylori infection.

ABSTRACT:

Background

In vitro studies have shown that Helicobacter pylori (H. pylori) infection induces autophagy in gastric epithelial cells. However, prolonged exposure to H. pylori reduces autophagy by preventing maturation of the autolysosome. The alterations of the autophagy-related genes in H. pylori infection are not yet fully understood.

Materials and methods

We analyzed autophagy-related gene expression in H. pylori-infected gastric mucosa compared with uninfected gastric mucosa obtained from 136 Bhutanese volunteers with mild dyspeptic symptoms. We also studied single nucleotide polymorphisms (SNPs) of autophagy-related gene in 283 Bhutanese participants to identify the influence on susceptibility to H. pylori infection.

Results

Microarray analysis of 226 autophagy-re

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC5422124 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature