A loss of profilin-1 in late-stage oral squamous cell carcinoma.

ABSTRACT:

Background

The genes for PFN1 and TMSB4 are both highly expressed in oral tissue and both encode actin monomer binding proteins thought to play a role in cell motility and possibly other crucial parts of tumor progression.

Methods

Oral brush cytology of epithelium from oral squamous cell carcinoma (OSCC) was used to measure PFN1 and TMSB4 mRNA in OSCC, while immunohistochemical analysis of tissue was used to check protein levels.

Results

High but variable expression of mRNAs encoding these two proteins was observed suggesting they may contribute to tumor characteristics in a subset of OSCCs. Both proteins were highly expressed in normal appearing basal epithelium, in the cytoplasm, and perinuclear area, while expression was minimal in upper epithelial layers. In OSCCs

SUBMITTER: Adami GR 

PROVIDER: S-EPMC5422140 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature