Preparation of zein nanoparticles by using solution-enhanced dispersion with supercritical CO₂ and elucidation with computational fluid dynamics.

ABSTRACT: Nanoparticles have attracted more and more attention in the medicinal field. Zein is a biomacromolecule and can be used as a carrier for delivering active ingredients to prepare controlled release drugs. In this article, we presented the preparation of zein nanoparticles by solution-enhanced dispersion by supercritical CO₂ (SEDS) approach. Scanning electron microscopy and transmission electron microscopy were applied to characterize the size and morphology of the obtained particles. The nozzle structure and the CO₂ flow rate greatly affected the morphology and the size of the particles. The size of zein was able to be reduced to 50-350 nm according to the different conditions. The morphologies of the resultant zein were either sphere or the filament network consisted

SUBMITTER: Li S 

PROVIDER: S-EPMC5422457 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature