Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells.

ABSTRACT: Leucine-rich-repeat-containing protein 26 (LRRC26) is the regulatory γ1 subunit of Ca²⁺- and voltage-dependent BK-type K⁺ channels. BK channels that contain LRRC26 subunits are active near normal resting potentials even without Ca²⁺, suggesting they play unique physiological roles, likely limited to very specific cell types and cellular functions. By using Lrrc26 KO mice with a β-gal reporter, Lrrc26 promoter activity is found in secretory epithelial cells, especially acinar epithelial cells in lacrimal and salivary glands, and also goblet and Paneth cells in intestine and colon, although absent from neurons. We establish the presence of LRRC26 protein in eight secretory tissues or tissues with significant secretory epithelium and show that LR

SUBMITTER: Yang C 

PROVIDER: S-EPMC5422807 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature