Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice.

ABSTRACT:

Background

Sepsis is a life-threatening complication of an infection and remains one of the leading causes of mortality in surgical patients. Bacteremia induces excessive inflammatory responses that result in multiple organ damage. Chronic helminth infection and helminth-derived materials have been found to immunomodulate host immune system to reduce inflammation against some allergic or inflammatory diseases. Schistosoma japonicum cystatin (Sj-Cys) is a cysteine protease inhibitor that induces regulatory T-cells and a potential immunomodulatory. The effect of Sj-Cys on reducing sepsis inflammation and mortality was investigated.

Methods

Sepsis was induced in BALB/c mice using cecal ligation and puncture (CLP), followed by intraperitoneal injection of different doses (10, 25

SUBMITTER: Li H 

PROVIDER: S-EPMC5422996 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature