Ontology highlight
ABSTRACT:
SUBMITTER: Mazor R
PROVIDER: S-EPMC5423085 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Mazor Ronit R Crown Devorah D Addissie Selamawit S Jang Youjin Y Kaplan Gilad G Pastan Ira I
Cellular & molecular immunology 20151019 5
Antibodies against the toxin portion of recombinant immunotoxins (RIT) reduce their efficacy and pose a potential safety risk. To overcome this problem we mutated the very immunogenic immunotoxin SS1P to produce LMB-T20, a de-immunized RIT that has the eight human T-cell epitopes in SS1P modified or removed. To determine the effect of T-cell epitope removal in vivo we mapped the T-cell epitopes in immune-competent BALB/c mice and found that these mice recognize two epitopes. One corresponds to t ...[more]